Grease: Observatory of the Breast cancer practices in France

Objectif(s) de la recherche et intérêt pour la santé publique

Finalité de l'étude

Objectifs poursuivis

Domaines médicaux investigués

Bénéfices attendus

L'objectif principal de cette étude est d'évaluer l'épidémiologie (prévalence, incidence)
du cancer du sein en France sur la période 2010-2023 et de décrire la prise en charge
thérapeutique des patients atteints de cancer du sein et son évolution dans le temps
The secondary objectives are to:
1. Describe the natural history of the BC
2. Describe the disease evolution: overall survival (OS) over time
3. Assess the effectiveness of specific treatments through the analysis of overall survival (OS), time to next treatment (TNT) and proportion of long-term responders,
4. Assess the evolution of BC healthcare pathway, including hospitalization care pathways
(hospital at-home, outpatient ambulatory, length of stay for conventional surgical
hospitalization); supportive care treatments, oncogenetic visits.
5. Describe the healthcare resource use of BC (treatments, consultations of healthcare
professionals, paramedical acts, medical procedures, laboratory tests, drugs, medical
devices, medical transports, sick leaves)
6. Assess the persistence and the compliance of BC specific treatments distributed in pharmacies outside the hospital (oral, intramuscular and subcutaneous forms) in the adjuvant setting
7. Assess the correlation between Time to first-line (1L) therapy discontinuation in metastatic stage of BC and OS

Justification of the public interest: In the light of the new BC treatments available, this
study will help to better understand healthcare management and update BC
epidemiology. Furthermore, by describing the burden of the disease, results of this study
could support the development of new treatments and the future discussions between
Roche and the French National Authority for Health.
Methodologie
Database: ESND
Profondeur historique: 19 ans en plus de l’année en cours
Design: This is a retrospective observational study using secondary data from the ESND database related to all adult women with a marker of BC management in France.
Population d'étude:
all French women from the ESND treated for an incident BC
between 1 January 2010 and 31 December 2022